Projekte & Publikationen COVID-19 Projekte an der Universität Bern

COVID-19 Forschung

Verschiedene Gruppen an der Universität Bern und des Inselspitals (Universitätsspitals Bern) forschen an COVID-19. Auf dieser Seite finden Sie eine Liste der Projekte.

Laufende COVID-19 Projekte

VACCELERATE

Projekttitel: European Corona Vaccine Trial Accelerator Platform
Ziele: To develop a platform for trial design and conduct and accelerate phase 2 & 3 COVID-19 vaccine trials.
PI: Sven Trelle
Dauer: 28. Januar 2021 – 27. Januar 2024
Programm: Health, Demographic Change and Wellbeing (Societal Challenge 1)
Projekttyp: Research & Innovation Action (mehrere Partner)
Details: Webseite

EpiPose

Projekttitel: Epidemic intelligence to minimize 2019-nCoV’s public health, economic and social impact in Europe
Ziele: To provide answers about the epidemiological characteristics of COVID-19, the social dynamics of the outbreak, and the public health preparedness and response, as well as to assess its economic impact.
PI: Christian Althaus, Nicola Low
Dauer: 13. März 2020 – 12. April 2023
Programm: Health, Demographic Change and Wellbeing (Societal Challenge 1)
Projekttyp: Research & Innovation Action (mehrere Partner)
Details: Webseite

Tracking the COVID-19 epidemic in Switzerland: phylogenetics and epidemiological modeling

Ziele: To integrate genomic epidemiology and epidemiological modeling in order to provide comprehensive inferences and projections for the COVID-19 epidemic in real-time.
Projektverantwortliche: Christian Althaus
Dauer: 1. Juni 2020 – 31. Mai 2022
Förderungsinstrument: Sonderausschreibung Coronaviren
Details: SNF Webseite

How to protect healthcare workforce during an epidemic outbreak: Modelling a desynchronization strategy from the COVID-19 pandemic

Ziele: To identify if organizational measures introduced during the COVID-19 outbreak were effective in protecting caregivers.
Projektverantwortliche: Guido Beldi, Daniel Sanchez Taltavull
Dauer: 1. Juni 2020 – 31. Mai 2022
Förderungsinstrument: Sonderausschreibung Coronaviren
Details: SNF Webseite

Unravelling consequences of SARS-CoV-2 mediated inflammatory immune responses in heart and vasculature

Ziele: To study if disease progression is dependent on the vascular cell type infected and provide insight into downstream signaling events.
Projektverantwortliche: Yvonne Döring, Robert Rieben, Nadia Mercader, Britta Engelhardt
Dauer: 1. September 2020 – 31. August 2022
Förderungsinstrument: NFP 78 Covid-19
Details: SNF Webseite

New insights into the COVID-19 pandemic: Genetic polymorphisms, role of SLC6 amino acid transporters, renal aspects and therapeutic perspectives

Ziele: To clarify the role of genetics in conferring COVID-19 severity and to screen for blockers of viral susceptibility to aid the development of treatment strategies
Projektverantwortliche: Matthias Hediger, Bruno Vogt
Dauer: 1. November 2020 – 31. Oktober 2022
Förderungsinstrument: NFP 78 Covid-19
Details: SNF Webseite

A multidisciplinary approach to identify vulnerabilities of SARS-CoV-2 for vaccine development

Ziele: To identify vulnerabilities of the virus during its usurpation of the host cell, specifically aspects that it may use to hijack host translation.
Projektverantwortliche: Sebastian Leidel, Volker Thiel
Dauer: 1. Juni 2020 – 31. Mai 2022
Förderungsinstrument: Sonderausschreibung Coronaviren
Details: SNF Webseite

Longitudinal single B cell studies across the trajectory of COVID-19 to identify SARS-CoV-2 specific monoclonal antibodies and long-term memory formation

Ziele: To describe the acute B cell response to SARS-CoV-2 at the single-cell level and determine if cellular B cell memory is formed in COVID-19 infection.
Projektverantwortliche: Andrew Macpherson, Stephanie Ganal-Vonarburg
Dauer: 1. Juni 2020 – 31. Mai 2022
Förderungsinstrument: Sonderausschreibung Coronaviren
Details: SNF Webseite

Neutralizing multivalent antibodies against coronaviruses

Ziele: To develop neutralizing multivalent single-chain antibodies (nmAb) to efficiently block viral cell-entry.
Projektverantwortliche: Philippe Plattet, Dimitrios Fotiadis
Dauer: 1. August 2020 – 31. Juli 2022
Förderungsinstrument: NFP 78 Covid-19
Details: SNF Webseite

AI-multi-omics-based prognostic stratification of COVID-19 patients in acute and chronic state

Ziele: To investigate whether an ensemble of multi-omic, patient-specific information can be used to predict patient outcome and ultimately optimize patient care.
Projektverantwortliche: Alexander Pöllinger, Mauricio Reyes
Dauer: 1. August 2020 – 31. Juli 2022
Förderungsinstrument: NFP 78 Covid-19
Details: SNF Webseite

Mixed-method evaluation of an online forward triage tool within the COVID-19 pandemic

Ziele: To study the utility of the first online forward triage tool for COVID-19 and the outcomes of using such a tool.
Projektverantwortliche: Thomas Sauter, Wolf Hautz, Meret Ricklin, Philipp Jent
Dauer: 1. Juni 2020 – 31. Mai 2022
Förderungsinstrument: Sonderausschreibung Coronaviren
Details: SNF Webseite

A continuously updated meta-ecological study of the effects of the COVID-19 pandemic on mental health, alcohol/substance abuse and violence in the general population

Ziele: To investigate mental health problems associated with the COVID-19 pandemic and the resulting lockdown.
Projektverantwortliche: Georgia Salanti
Dauer: 1. August 2020 – 31. Juli 2022
Förderungsinstrument: NFP 78 Covid-19
Details: SNF Webseite

Devils dance: complement, NETs and thrombosis in COVID-19

Ziele: To identify the pathways involved in complement and neutrophil activation that lead to the development of acute respiratory distress syndrome and microvascular complications in COVID-19.
Projektverantwortliche: Sacha Zeerleder
Dauer: 1. September 2020 – 31. August 2022
Förderungsinstrument: NFP 78 Covid-19
Details: SNF Webseite

(alphabetisch nach Geldgeber aufgelistet)

ACE2, TMPRSS2 and SLC6A15 variants as candidates of shaping the COVID-19 severity

Ziele: To investigate the roles of genetic variations of specific human host genes in the predisposition to COVID-19 infection and disease severity.
Inselspital PIs: Matthias Hediger, Bruno Vogt
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

How to protect healthcare workforce during pandemics: Determining the consequences of testing asymptomatic co-workers after the first wave of the COVID-19 outbreak

Ziele: To determine the effect of continuous testing of asymptomatic caregivers on the protection of the healthcare workforce and patients in each stage of a pandemic.
PIs: Guido Beldi, Daniel Sánchez-Taltavull
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Identification of Patient-specific Master Regulator Proteins Associated with SARS-CoV-2-Infection and Pulmonary Fibrosis in Lung-on-Chip

Ziele: To characterize molecular pathways of SARS-CoV-2 infection and phenotypic changes in lung alveolar epithelial cells in order to identify alterations that trigger fibrosis.
Uni Bern/Inselspital PI: Thomas Geiser
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Investigation of the local and systemic immune system regulation in COVID-19

Ziele: To analyze cells in the lung lavage of COVID-19 patients to determine how and which immune cells are activated during COVID-19.
Uni Bern/Inselspital PI: Philippe Krebs
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Investigation of the performance of Gas6 plasma level as predictor of disease severity, thromboembolism occurrence and mortality in patients with COVID-19

Ziele: To assess the performance of Gas6 as predictor of disease severity, thromboembolism occurrence and mortality in patients with COVID-19.
Uni Bern/Inselspital PI: Anne Angelillo-Scherrer
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Impact of aging on pulmonary long-term effects after COVID-19

Ziele: A Swiss national prospective observational study to evaluate pulmonary long-term effects of COVID-19.
Uni Bern/Inselspital PI: Manuela Funke-Chambour
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

ROCO – Online Selbsthilfe für psychische Belastung durch COVID-19

Ziele: To investigate the effectiveness of a 3-week online self-help program for people who feel psychologically stressed due to the situation surrounding COVID-19.
Uni Bern PIs: Thomas Berger, Hansjörg Znoj
Geldgeber: Eigenmittel
Details: Webseite

The European Academy of Neurology COVID-19 registry (ENERGY)

Ziele: To collect epidemiological data on neurological manifestations in patients with COVID-19 infection.
Uni Bern PI: Claudio Bassetti, Simon Jung (EAN Neuro-COVID Task Force)
Geldgeber: European Academy of Neurology
Details: Webseite

Corona-Memory.ch

Ziele: To collect, study and make available in the long term first-hand narratives on how civil society is experiencing or has experienced this difficult moment.
Uni Bern PI: Tobias Hodel
Dauer: 1. Mai 2020 – 31. Dezember 2020
Geldgeber: Fondation Petram; Migros Kulturprozent
Details: Webseite

CORON-ACT

Ziele: The mulitcenter clinical trial aims to test the efficacy and safety of tocilizumab in the treatment of progressing COVID-19.
Inselspital PI: Peter M. Villiger
Uni Bern Kontakt: Stephan Reichenbach
Dauer: April 2020 – Oktober 2020
Geldgeber: Inselspital
Details: Webseite

DARVID - Distress, Anxiety and Resilience among Health Care Professionals during the COVID-19-Pandemic

Ziele: To investigate how personal resilience and sense of coherence during the COVID-19 pandemic affects the mental health of healthcare professionals.
Uni Bern Kontakt: Sandra Abegglen
Dauer: 15. März 2020 – 1. Januar 2021
Geldgeber: Inselspital
Details: Webseite

EUCLID

Ziele: To study the perception and behavior of the population in the areas of subjective health, perception of risks, protection motivation and behaviour, and expected future developments of the current coronavirus outbreak.
Uni Bern PI: Jennifer Inauen
Geldgeber: Verschiedene
Details: Webseite

Public health emergency SOLIDARITY trial of treatments for COVID-19 infection in hospitalized patients

Ziele: The mulitcenter clinical trial aims to test antiviral drugs in a controlled manner that are currently used to treat COVID-19.
Inselspital PIs: Hansjakob Furrer, Andri Rauch
Dauer: März 2020 – März 2021
Geldgeber: World Health Organization; Schweizerischer Nationalfonds
Details: Webseite

Internationale Datenbanken

Es gibt zahlreiche Datenbanken mit Informationen über die internationale Forschung zu COVID-19 sowie zu den verfügbaren Daten. Nachstehend finden Sie eine kleine Auswahl.