DIGIPREDICT

Projekttitel: Edge AI-deployed digital twins for predicting disease progression and need for early intervention in infectious and cardiovascular diseases beyond COVID-19
Ziele: To develop an AI-based system to predict whether COVID-19 patients will develop severe cardiovascular complications and detect the likely onset of inflammatory disease.
PI: Wolf Hautz
Dauer: 1. Januar 2021 – 31. Dezember 2024
Programm: Future and Emerging Technologies (FET) Proactive
Projekttyp: Research & Innovation Action (mehrere Partner)
Details: Webseite

VACCELERATE

Projekttitel: European Corona Vaccine Trial Accelerator Platform
Ziele: To develop a platform for trial design and conduct and accelerate phase 2 & 3 COVID-19 vaccine trials.
PI: Cornelia Staehelin, Sven Trelle
Dauer: 28. Januar 2021 – 27. Januar 2024
Programm: Health, Demographic Change and Wellbeing (Societal Challenge 1)
Projekttyp: Research & Innovation Action (mehrere Partner)
Details: Webseite

EpiPose

Projekttitel: Epidemic intelligence to minimize 2019-nCoV’s public health, economic and social impact in Europe
Ziele: To provide answers about the epidemiological characteristics of COVID-19, the social dynamics of the outbreak, and the public health preparedness and response, as well as to assess its economic impact.
PI: Christian Althaus, Nicola Low
Dauer: 13. März 2020 – 12. April 2023
Programm: Health, Demographic Change and Wellbeing (Societal Challenge 1)
Projekttyp: Research & Innovation Action (mehrere Partner)
Details: Webseite

Tracking the COVID-19 epidemic in Switzerland: phylogenetics and epidemiological modeling

Ziele: To integrate genomic epidemiology and epidemiological modeling in order to provide comprehensive inferences and projections for the COVID-19 epidemic in real-time.
Projektverantwortliche: Christian Althaus
Dauer: 1. Juni 2020 – 31. Dezember 2022
Förderinstrument: Sonderausschreibung Coronaviren
Details: SNF Webseite

Unravelling consequences of SARS-CoV-2 mediated inflammatory immune responses in heart and vasculature

Ziele: To study if disease progression is dependent on the vascular cell type infected and provide insight into downstream signaling events.
Projektverantwortliche: Yvonne Döring, Britta Engelhardt, Nadia Mercader, Robert Rieben
Dauer: 1. November 2020 – 30. Juni 2023
Förderinstrument: NFP 78 Covid-19
Details: SNF Webseite

New insights into the COVID-19 pandemic: Genetic polymorphisms, role of SLC6 amino acid transporters, renal aspects and therapeutic perspectives

Ziele: To clarify the role of genetics in conferring COVID-19 severity and to screen for blockers of viral susceptibility to aid the development of treatment strategies
Projektverantwortliche: Matthias Hediger, Bruno Vogt
Dauer: 1. November 2020 – 31. Oktober 2022
Förderinstrument: NFP 78 Covid-19
Details: SNF Webseite

Neutralizing multivalent antibodies against coronaviruses

Ziele: To develop neutralizing multivalent single-chain antibodies (nmAb) to efficiently block viral cell-entry.
Projektverantwortliche: Dimitrios Fotiadis, Philippe Plattet
Dauer: 1. September 2020 – 31. August 2022
Förderinstrument: NFP 78 Covid-19
Details: SNF Webseite

AI-multi-omics-based prognostic stratification of COVID-19 patients in acute and chronic state

Ziele: To investigate whether an ensemble of multi-omic, patient-specific information can be used to predict patient outcome and ultimately optimize patient care.
Projektverantwortliche: Alexander Pöllinger, Mauricio Reyes
Dauer: 1. November 2020 – 30. April 2023
Förderinstrument: NFP 78 Covid-19
Details: SNF Webseite

A continuously updated meta-ecological study of the effects of the COVID-19 pandemic on mental health, alcohol/substance abuse and violence in the general population

Ziele: To investigate mental health problems associated with the COVID-19 pandemic and the resulting lockdown.
Projektverantwortliche: Georgia Salanti
Dauer: 1. Oktober 2020 – 30. September 2022
Förderinstrument: NFP 78 Covid-19
Details: SNF Webseite

Devils dance: complement, NETs and thrombosis in COVID-19

Ziele: To identify the pathways involved in complement and neutrophil activation that lead to the development of acute respiratory distress syndrome and microvascular complications in COVID-19.
Projektverantwortliche: Sacha Zeerleder
Dauer: 1. Oktober 2020 – 30. September 2022
Förderinstrument: NFP 78 Covid-19
Details: SNF Webseite

(alphabetisch nach Geldgeber aufgelistet)

ACE2, TMPRSS2 and SLC6A15 variants as candidates of shaping the COVID-19 severity

Ziele: To investigate the roles of genetic variations of specific human host genes in the predisposition to COVID-19 infection and disease severity.
Inselspital PIs: Matthias Hediger, Bruno Vogt
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

How to protect healthcare workforce during pandemics: Determining the consequences of testing asymptomatic co-workers after the first wave of the COVID-19 outbreak

Ziele: To determine the effect of continuous testing of asymptomatic caregivers on the protection of the healthcare workforce and patients in each stage of a pandemic.
PIs: Guido Beldi, Daniel Sánchez-Taltavull
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Identification of Patient-specific Master Regulator Proteins Associated with SARS-CoV-2-Infection and Pulmonary Fibrosis in Lung-on-Chip

Ziele: To characterize molecular pathways of SARS-CoV-2 infection and phenotypic changes in lung alveolar epithelial cells in order to identify alterations that trigger fibrosis.
Uni Bern/Inselspital PI: Thomas Geiser
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Investigation of the local and systemic immune system regulation in COVID-19

Ziele: To analyze cells in the lung lavage of COVID-19 patients to determine how and which immune cells are activated during COVID-19.
Uni Bern/Inselspital PI: Philippe Krebs
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Investigation of the performance of Gas6 plasma level as predictor of disease severity, thromboembolism occurrence and mortality in patients with COVID-19

Ziele: To assess the performance of Gas6 as predictor of disease severity, thromboembolism occurrence and mortality in patients with COVID-19.
Uni Bern/Inselspital PI: Anne Angelillo-Scherrer
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

Impact of aging on pulmonary long-term effects after COVID-19

Ziele: A Swiss national prospective observational study to evaluate pulmonary long-term effects of COVID-19.
Uni Bern/Inselspital PI: Manuela Funke-Chambour
Geldgeber: Bern Center for Precision Medicine
Details: Webseite

ROCO – Online Selbsthilfe für psychische Belastung durch COVID-19

Ziele: To investigate the effectiveness of a 3-week online self-help program for people who feel psychologically stressed due to the situation surrounding COVID-19.
Uni Bern PIs: Thomas Berger, Hansjörg Znoj
Geldgeber: Eigenmittel
Details: Webseite

The European Academy of Neurology COVID-19 registry (ENERGY)

Ziele: To collect epidemiological data on neurological manifestations in patients with COVID-19 infection.
Uni Bern PI: Claudio Bassetti, Simon Jung (EAN Neuro-COVID Task Force)
Geldgeber: European Academy of Neurology
Details: Webseite

CONSIGN - COVID-19 infection and medicines In pregnancy

Ziele: To provide data on the impact of COVID-19 in pregnancy to guide decision-making about vaccine indications, vaccination policies, and treatment options for COVID-19 disease and associated complications.
Uni Bern PI: Alice Panchaud
Geldgeber: European Medicines Agency (University Medical Center Utrecht)

Corona-Memory.ch

Ziele: To collect, study and make available in the long term first-hand narratives on how civil society is experiencing or has experienced this difficult moment.
Uni Bern PI: Tobias Hodel
Dauer: 1. Mai 2020 – 31. Dezember 2020
Geldgeber: Fondation Petram; Migros Kulturprozent
Details: Webseite

CORON-ACT

Ziele: The mulitcenter clinical trial aims to test the efficacy and safety of tocilizumab in the treatment of progressing COVID-19.
Inselspital PI: Peter M. Villiger
Uni Bern Kontakt: Stephan Reichenbach
Dauer: April 2020 – Oktober 2020
Geldgeber: Inselspital
Details: Webseite

DARVID - Distress, Anxiety and Resilience among Health Care Professionals during the COVID-19-Pandemic

Ziele: To investigate how personal resilience and sense of coherence during the COVID-19 pandemic affects the mental health of healthcare professionals.
Uni Bern Kontakt: Sandra Abegglen
Dauer: 15. März 2020 – 1. Januar 2021
Geldgeber: Inselspital
Details: Webseite

EUCLID

Ziele: To study the perception and behavior of the population in the areas of subjective health, perception of risks, protection motivation and behaviour, and expected future developments of the current coronavirus outbreak.
Uni Bern PI: Jennifer Inauen
Geldgeber: Verschiedene
Details: Webseite

Public health emergency SOLIDARITY trial of treatments for COVID-19 infection in hospitalized patients

Ziele: The mulitcenter clinical trial aims to test antiviral drugs in a controlled manner that are currently used to treat COVID-19.
Inselspital PIs: Hansjakob Furrer, Andri Rauch
Dauer: März 2020 – März 2021
Geldgeber: World Health Organization; Schweizerischer Nationalfonds
Details: Webseite